{"id":3392,"date":"2020-11-13T14:52:27","date_gmt":"2020-11-13T12:52:27","guid":{"rendered":"https:\/\/geneceutica.ro\/persoanele-cu-deficit-de-diaminoxidaza-expuse-la-forme-agravate-de-covid-19\/"},"modified":"2023-03-22T15:23:55","modified_gmt":"2023-03-22T13:23:55","slug":"persoanele-cu-deficit-de-diaminoxidaza-expuse-la-forme-agravate-de-covid-19","status":"publish","type":"post","link":"https:\/\/geneceutica.ro\/en\/persoanele-cu-deficit-de-diaminoxidaza-expuse-la-forme-agravate-de-covid-19\/","title":{"rendered":"Persoanele cu deficit de diaminoxidaz\u0103 \u2013 expuse la forme agravate de COVID 19"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3392\" class=\"elementor elementor-3392 elementor-238\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6982eaa elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6982eaa\" data-element_type=\"section\" data-settings=\"{&quot;_ob_glider_is_slider&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9cdf61e\" data-id=\"9cdf61e\" data-element_type=\"column\" data-settings=\"{&quot;_ob_column_hoveranimator&quot;:&quot;no&quot;,&quot;_ob_column_has_pseudo&quot;:&quot;no&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-009f65e ob-harakiri-inherit ob-has-background-overlay elementor-widget elementor-widget-text-editor\" data-id=\"009f65e\" data-element_type=\"widget\" data-settings=\"{&quot;_ob_use_harakiri&quot;:&quot;yes&quot;,&quot;_ob_harakiri_writing_mode&quot;:&quot;inherit&quot;,&quot;_ob_postman_use&quot;:&quot;no&quot;,&quot;_ob_widget_stalker_use&quot;:&quot;no&quot;,&quot;_ob_poopart_use&quot;:&quot;yes&quot;,&quot;_ob_shadough_use&quot;:&quot;no&quot;,&quot;_ob_allow_hoveranimator&quot;:&quot;no&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Epidemia de coronavirus a acaparat la cote maxime interesul comunit\u0103\u021bii \u0219tiin\u021bifice \u00een ultimele luni, cercet\u0103torii \u00eencerc\u00e2nd cu obstina\u021bie s\u0103 g\u0103seasca noi c\u0103i de control al acestui virus pe c\u00e2t de minuscul, pe at\u00e2t de devastator la nivel mondial.<\/p><p>Ve\u0219ti noi vin din direc\u021bii de cercetare inedite, pentru c\u0103 prezen\u021ba unor comorbidit\u0103\u021bi poate pune \u00a0la grea \u00eencercare at\u00e2t pacien\u021bii infecta\u021bi, c\u00e2t si personalul medical de \u00eengrjire, schimb\u00e2nd, adesea dramatic, cursul bolii. Dac\u0103 obezitatea, diabetul decompensat sau tulbur\u0103rile de coagulare pot induce f\u0103r\u0103 dubiu forme agravate sau chiar letale ale acestei viroze, cercet\u0103torii au descoperit \u00a0\u0219i c\u0103 \u00a0deficien\u021ba sau prezen\u021ba unor modific\u0103ri genetice poate altera reactivitatea \u00a0organismului \u0219i contribui la forme agresive ale Covid19.<\/p><p><strong><b>Deficien\u021ba unei enzime denumit\u0103 diaminoxidaza (DAO), tradus\u0103 prin a\u0219a zisa intoleran\u021b\u0103 la histamin\u0103, merit\u0103 men\u021bionat\u0103, publica\u021bii recente sus\u021bin\u00e2nd faptul c\u0103 activarea mastocitelor \u0219i eliberarea histaminei pot contribui la inflama\u021bia asociat\u0103 cu infec\u021bia cu SARS COV-2. <\/b><\/strong><\/p><p><strong><b>Cum recunoa\u0219tem persoanele cu o posibil\u0103 deficien\u021b\u0103 de diaminoxidaz\u0103 (DAO)?<\/b><\/strong><\/p><p>Persoanele cu deficit de diaminoxidaz\u0103 au \u00een general manifest\u0103ri polimorfe cronice, ca de exemplu migrene, dureri de cap frecvente, piele uscat\u0103, dermatit\u0103 atopic\u0103, uneori crize de astm, ADHD, intestin iritabil sau oboseal\u0103 cronic\u0103, dureri musculare sau fibromialgii. Simptomele se agraveaz\u0103 dup\u0103 ingestia unor alimente cu con\u021binut crescut de histamin\u0103 cum ar fi alcoolul, br\u00e2nzeturi fermentate, anumite tipuri de pe\u0219te, c\u0103p\u0219uni,vinete, \u00a0lapte crud, salamuri sau c\u00e2rna\u021bi, etc<\/p><p>Pacien\u021bii pot suferi ani de zile de aceste simptome, adesea combinate, dar cauza adev\u0103rat\u0103,\u0219i \u00a0anume anomalia genetic\u0103 ce a dus la deficitul enzimei DAO, r\u0103m\u00e2ne necunoscut\u0103 \u00een lipsa unui <strong><b>test salivar genetic, \u00a0revelator, neinvaziv si simplu care identific\u0103 muta\u021biile genei AOC1.<\/b><\/strong>\u00a0Un fapt important este c\u0103 simptomele acestor pacien\u021bi apar sau se agraveaz\u0103 dup\u0103 ingestia unor alimente cu con\u021binut crescut de histamin\u0103 cum ar fi alcoolul, br\u00e2nzeturi fermentate, anumite tipuri de pe\u0219te, c\u0103p\u0219uni,vinete, \u00a0lapte crud, salamuri sau c\u00e2rna\u021bi, etc<\/p><p><strong><b>\u00a0<\/b><\/strong><\/p><p><strong><b>Interac\u021biunea SARS-COV2 cu mastocitele tractului respirator<\/b><\/strong><\/p><p>Infec\u021bia cu coronavirus (indiferent de diferitele tipuri de coronavirus) este atacat\u0103 \u00een primul r\u00e2nd de celulele imune, inclusiv mastocitele (MC), care se g\u0103sesc \u00een submucoasa tractului respirator \u0219i \u00een cavitatea nazal\u0103, reprezent\u00e2nd o barier\u0103 de protec\u021bie \u00eempotriva microorganismelor.<\/p><p>Viru\u0219ii activeaz\u0103 mastocitele care elibereaz\u0103 compu\u0219i chimici inflamatori timpurii, cum ar fi histamina \u0219i proteaza (1). Persoanele cu deficit de DAO, o enzim\u0103 implicat\u0103 \u00een degradarea histamine exogene \u00een principal, au niveluri ridicate de histamin\u0103 circulant\u0103, \u0219i, de aceea, o acumulare mai mare de histamin\u0103 cauzat\u0103 de mastocitoza activat\u0103 de virus men\u021bionat\u0103 anterior, poate agrava procesul inflamator generat de infec\u021bie.<\/p><p>\u00cen condi\u021bii normale, atunci c\u00e2nd nivelurile de histamin\u0103 cresc peste un anumit prag, enzimele responsabile de metabolismul s\u0103u, \u00een special DAO (diaminoxidaza) \u0219i, \u00eentr-o m\u0103sur\u0103 mai mic\u0103, histamin N-metil transferaza (HNMT), degradeaz\u0103 rapid excesul de aceast\u0103 amin\u0103. Cu toate acestea, atunci c\u00e2nd rata de degradare este insuficient\u0103 pentru a face fa\u021b\u0103 excesului, nivelul total de histamin\u0103 din organism cre\u0219te. La un anumit nivel critic, semnele \u0219i simptomele apar ca urmare a cupl\u0103rii histaminei la receptorii s\u0103i din celule specifice.<\/p><p>Histamina este un mediator care intervine \u00een inflama\u021bia sistemului imunitar prin activarea c\u0103ilor intracelulare care induc produc\u021bia de citokine \u00een pl\u0103m\u00e2ni. Citokinele sunt proteine \u200b\u200bde semnalizare care regleaz\u0103 interac\u021biunile celulelor sistemului imunitar, produc\u00e2nd astfel o amplificare a reac\u021biilor inflamatorii.<\/p><p><strong><b>Ce trebuie s\u0103 fac\u0103 persoanele cu deficit de DAO \u0219i intoleran\u021b\u0103 la histamin\u0103 pentru reducerea impactului infec\u021biei cu Sars-Cov2?<\/b><\/strong><\/p><p>Pe baza studiilor men\u021bionate anterior \u0219i a fiziopatologiei bolii, este important s\u0103 se maximizeze recomand\u0103rile de baz\u0103 pentru a proteja \u00eempotriva COVID-19, evit\u00e2nd acumularea de histamin\u0103 la persoanele cu deficit de DAO \u0219i \/ sau mastocitoz\u0103. Deoarece inflama\u021bia este o preocupare a gravit\u0103\u021bii bolii cauzate de SARS COV-2, se recomand\u0103 reducerea consumului de alimente bogate \u00een histamin\u0103 \u00een diet\u0103 \u0219i administrarea de suplimente care s\u0103 permit\u0103 men\u021binerea unui echilibru \u00eentre histamina endogen\u0103 \u0219i cea exogen\u0103, evit\u00e2nd un exces de histamin\u0103 \u00een organism \u0219i, prin urmare, reducerea sarcinii mastocitare \/ histaminei.<\/p><p>Astfel, pe l\u00e2ng\u0103 liniile directoare generale de baz\u0103 pentru a preveni r\u0103sp\u00e2ndirea COVID-19 \u00een \u00eentreaga popula\u021bie, exist\u0103 o serie de recomand\u0103ri ad\u0103ugate de luat \u00een considerare la persoanele cu deficit de DAO \u0219i \/ sau intoleran\u021b\u0103 la histamin\u0103:<\/p><p>-Evitarea consumului de alimente cu o concentra\u021bie mare de histamin\u0103 sau altor amine biogene care concureaz\u0103 pentru enzima DAO. Acestea includ, de exemplu, lapte crud, pasteurizat \u0219i produse lactate; citrice, c\u0103p\u0219uni \u0219i banane; fructe de mare, pe\u0219te albastru \u0219i sosuri de pe\u0219te; c\u00e2rna\u021bii cruzi, precum c\u00e2rna\u021bi chorizo sau sl\u0103nin\u0103; unele legume, cum ar fi ro\u0219iile, spanacul sau vinetele, precum \u0219i b\u0103uturile alcoolice.<\/p><p><strong><b>Suplimentarea oral\u0103 de enzim\u0103 DAO \u2013 pas esen\u021bial \u00een preven\u021bia complica\u021biilor acumul\u0103rii de histamin\u0103 \u00een organism<\/b><\/strong><\/p><p>-Suplimentarea oral\u0103 a enzimei DAO pentru a preveni absorb\u021bia sistemic\u0103 a histaminei exogene sau dietetice. Acest lucru faciliteaz\u0103 metabolismul histaminei alimentare la nivel local \u00een intestinul sub\u021bire, restabilind echilibrul natural al histaminei \u0219i al DAO.<\/p><p>\u2013DAOfood\u00ae Plus, un nutraceutic acreditat de autorit\u0103\u021bile de reglementare, con\u021bine enzima DAO care completeaz\u0103 propria enzim\u0103 a organismului \u0219i cre\u0219te capacitatea de degradare a histaminei exogene. De asemenea, con\u021bine Quercetin\u0103 care ac\u021bioneaz\u0103 ca adjuvant \u00eempotriva histaminei endogene. Aportul s\u0103u previne absorb\u021bia \u0219i acumularea histaminei circulante \u0219i, prin urmare, contracareaz\u0103 eliberarea histaminei endogene ca reac\u021bie a organismului atunci c\u00e2nd intr\u0103 \u00een contact cu virusul.<\/p><p>Este important de re\u021binut c\u0103, deoarece SARS COV-2 este clasificat ca o nou\u0103 tulpin\u0103 de coronavirus, exist\u0103 dovezi \u0219tiin\u021bifice limitate disponibile cu privire la modul s\u0103u precis de ac\u021biune \u0219i infec\u021bie. Prin urmare, ceea ce este indicat \u00een acest articol se bazeaz\u0103 pe ceea ce \u0219tim p\u00e2n\u0103 acum \u0219i pe importan\u021ba protej\u0103rii \u00eempotriva virusului, men\u021bin\u00e2nd \u00een acela\u0219i timp controlul asupra mastocitozei \u0219i a deficitului de DAO.<\/p><p>Referin\u021be:<\/p><p>1.- \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Kritas, S. K., Ronconi, G., Caraffa, A., Gallenga, C. E., Ross, R., &amp; Conti, P. (2020). Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy. Journal of biological regulators and homeostatic agents, 34(1), 10.23812\/20-Editorial-Kritas.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Epidemia de coronavirus a acaparat la cote maxime interesul comunit\u0103\u021bii \u0219tiin\u021bifice \u00een ultimele luni, cercet\u0103torii \u00eencerc\u00e2nd cu obstina\u021bie s\u0103 g\u0103seasca noi c\u0103i de control al acestui virus pe c\u00e2t de minuscul, pe at\u00e2t de devastator la nivel mondial. Ve\u0219ti noi vin din direc\u021bii de cercetare inedite, pentru c\u0103 prezen\u021ba unor comorbidit\u0103\u021bi poate pune \u00a0la grea [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2764,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[191,128],"tags":[172,173,131],"_links":{"self":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/posts\/3392"}],"collection":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/comments?post=3392"}],"version-history":[{"count":0,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/posts\/3392\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/media\/2764"}],"wp:attachment":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/media?parent=3392"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/categories?post=3392"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/tags?post=3392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}