{"id":3389,"date":"2021-02-28T17:31:42","date_gmt":"2021-02-28T15:31:42","guid":{"rendered":"https:\/\/geneceutica.ro\/vitamina-c-si-quercetina-investigate-de-cercetatori-in-privinta-efectelor-antivirale\/"},"modified":"2023-03-22T15:23:45","modified_gmt":"2023-03-22T13:23:45","slug":"vitamina-c-si-quercetina-investigate-de-cercetatori-in-privinta-efectelor-antivirale","status":"publish","type":"post","link":"https:\/\/geneceutica.ro\/en\/vitamina-c-si-quercetina-investigate-de-cercetatori-in-privinta-efectelor-antivirale\/","title":{"rendered":"Vitamina C si Quercetina &#8211; investigate de cercet\u0103tori \u00een privin\u021ba efectelor antivirale"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3389\" class=\"elementor elementor-3389 elementor-857\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1d860765 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1d860765\" data-element_type=\"section\" data-settings=\"{&quot;_ob_glider_is_slider&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-72567582\" data-id=\"72567582\" data-element_type=\"column\" data-settings=\"{&quot;_ob_column_hoveranimator&quot;:&quot;no&quot;,&quot;_ob_column_has_pseudo&quot;:&quot;no&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a85c9f4 ob-harakiri-inherit ob-has-background-overlay elementor-widget elementor-widget-text-editor\" data-id=\"7a85c9f4\" data-element_type=\"widget\" data-settings=\"{&quot;_ob_use_harakiri&quot;:&quot;yes&quot;,&quot;_ob_harakiri_writing_mode&quot;:&quot;inherit&quot;,&quot;_ob_postman_use&quot;:&quot;no&quot;,&quot;_ob_widget_stalker_use&quot;:&quot;no&quot;,&quot;_ob_poopart_use&quot;:&quot;yes&quot;,&quot;_ob_shadough_use&quot;:&quot;no&quot;,&quot;_ob_allow_hoveranimator&quot;:&quot;no&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<div>\n<div dir=\"auto\">Pare surprinz\u0103tor faptul c\u0103 laureat<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/geneceutica.ro\/wp-content\/uploads\/2021\/02\/130695517_113084510632485_1162900425572702726_n-300x251.png\" alt=\"\" width=\"300\" height=\"251\">ul premiului Nobel, Szent-Gyorgyi, a descoperit at\u00e2t acidul ascorbic (vitamina C), c\u00e2t \u0219i quercetina flavonoid\u0103 (la momentul respectiv etichetat\u0103 ca vitamina P). Acidul ascorbic este o vitamin\u0103 esen\u021bial\u0103 cu propriet\u0103\u021bi antivirale cunoscute , care este \u00een curs de investigare pentru efectele sale benefice \u00een timpul r\u0103spunsului la sepsis \u0219i la pacien\u021bii cu boli critice.<\/div>\n<div dir=\"auto\"><\/div>\n<div dir=\"auto\"><strong>Vitamina C<\/strong> \u00ee\u0219i exercit\u0103 propriet\u0103\u021bile antivirale prin sus\u021binerea activit\u0103\u021bii limfocitelor, cre\u0219terea produc\u021biei de interferon-\u03b1, modularea citokinelor, reducerea inflama\u021biei, \u00eembun\u0103t\u0103\u021birea disfunc\u021biei endoteliale \u0219i restabilirea func\u021biei mitocondriale. Exist\u0103, de asemenea, sugestii c\u0103 vitamina C poate fi direct virucid\u0103 .<\/div>\n<\/div>\n<div>\n<div dir=\"auto\"><\/div>\n<div dir=\"auto\"><strong><br><\/strong><\/div>\n<div dir=\"auto\"><strong>Quercetina<\/strong> (cunoscut\u0103 \u0219i sub numele de 3,3 \u2032, 4\u20325,7-pentahidroxiflavon\u0103) este un flavonoid vegetal larg distribuit, g\u0103sit \u00een mai multe legume, frunze, semin\u021be \u0219i cereale, unde este conjugat cu zaharuri reziduale pentru a forma glicozid quercetina. Studiile sugereaz\u0103 c\u0103 suplimentarea cu quercetin\u0103 poate favoriza efectele antioxidante, antiinflamatorii, antivirale \u0219i imunoprotectoare . Quercetina a fost studiat\u0103 \u00een diferite tipuri \u0219i modele de infec\u021bie viral\u0103 datorit\u0103 efectelor sale antivirale promi\u021b\u0103toare \u00een inhibarea polimerazelor , proteazei , transcriptazei inverse, suprimarea ADN-girazei \u0219i legarea proteinelor capsidei virale .<\/div>\n<\/div>\n<div>\n<div dir=\"auto\">Dar, multe studii indic\u0103 efectele complementare sau sinergice ale celor doi compu\u0219i \u00een infec\u021bii virale pentru care medicina modern\u0103 nu are prea multe solu\u021bii terapeutice.<\/div>\n<div dir=\"auto\"><\/div>\n<\/div>\n<div>\n<div dir=\"auto\"><strong><br><\/strong><\/div>\n<div dir=\"auto\"><strong>Efectele benefice ale vitaminei C \u0219i ale quercetinei \u00een infec\u021biile virale<\/strong><\/div>\n<div dir=\"auto\"><\/div>\n<\/div>\n<div>\n<div dir=\"auto\">Exist\u0103 o cantitate imens\u0103 de literatur\u0103 care sus\u021bine <strong>propriet\u0103\u021bile antivirale ale quercetinei<\/strong>, at\u00e2t \u00een experimente in vitro, c\u00e2t \u0219i in vivo. Quercetina inhib\u0103 mai mul\u021bi viru\u0219i respiratori \u00een celulele cultivate . Inhib\u0103 efectele citopatice provocate de multe serotipuri de rinovirus, echovirus (tip 7, 11, 12 \u0219i 19), coxsackievirus (A21 \u0219i B1) \u0219i poliovirus (tip 1 Sabin) la o concentra\u021bie inhibitoare minim\u0103 de 0,03 p\u00e2n\u0103 la 0,5 \u03bcg \/ ml \u00een celulele Hela sau WI-38. Quercetina reduce, de asemenea, semnificativ formarea pl\u0103cii de c\u0103tre virusurile ARN \u0219i ADN [Virusul respirator sinci\u021bial (RSV), poliomielita de tip 1, parainfluenza de tip 3 \u0219i Herpes Simplex Virus-1 (HSV-1)] care prezint\u0103 propriet\u0103\u021bi antiinfec\u021bioase \u0219i anti-replicative ). Inhib\u0103 replicarea celulelor HeLa inoculate de citomegalovirus (CMV) la o concentra\u021bie inhibitoare pe jum\u0103tate (IC50) de 3,2 \u00b1 0,8 \u03bcM \u0219i cu un indice de selectivitate (SI) de 22. Replicarea virusului Dengue tip 2 (DENV-2) \u00een celulele Vero este inhibat\u0103 de quercetin\u0103 la un IC50 de 35,7 \u03bcg \/ ml, provoc\u00e2nd o reducere a ARN-ului DENV-2 de 67%. Acest lucru este atribuit capacit\u0103\u021bii quercetinului de a bloca intrarea virusului sau de a inhiba enzimele de replicare viral\u0103, cum ar fi polimerazele virale .<\/div>\n<\/div>\n<div>\n<div dir=\"auto\">Studiile in vivo indic\u0103 faptul c\u0103 \u0219oarecii inocula\u021bi cu virusul meningoencefalitei sunt proteja\u021bi de infec\u021bia letal\u0103 prin quercetin\u0103 (30 sau 40 mg \/ Kg BID, po, timp de 4 zile) \u00eentr-o manier\u0103 dependent\u0103 de doz\u0103. Aceste efecte benefice sunt abolite dac\u0103 este administrata mai putin de 3 zile, o dat\u0103 pe zi sau prin injec\u021bie subcutanat\u0103. Acest lucru poate sugera c\u0103 efectele antivirale pot depinde de o concentra\u021bie inhibitoare minim\u0103 sau de o form\u0103 de conversie metabolic\u0103 a medicamentelor. Tratamentul cu quercetin\u0103 a prezentat, de asemenea, un efect benefic la \u0219oarecii imunocompeten\u021bi infecta\u021bi cu virusul Mengo, unde a sc\u0103zut severitatea leziunilor organelor.<\/div>\n<\/div>\n<div>\n<div dir=\"auto\">Sportivii suplimenta\u021bi cu quercetin\u0103 sunt proteja\u021bi de sensibilitatea indus\u0103 de stres la infec\u021bia tractului respirator superior.<\/div>\n<div dir=\"auto\"><\/div>\n<\/div>\n<div>\n<div dir=\"auto\"><strong><br><\/strong><\/div>\n<div dir=\"auto\"><strong>Vitamina C<\/strong> este un nutrient esen\u021bial implicat \u00eentr-o gam\u0103 divers\u0103 de func\u021bii imune; suplimentarea sa a demonstrat efecte benefice \u00een diferite tipuri de infec\u021bii virale. Niveluri reduse de ascorbat au fost g\u0103site la pacien\u021bii cu infec\u021bii virale, sepsis, ARDS legat de sepsis \u0219i alte boli critice . \u00cen timpul infec\u021biei, vitamina C este necesar\u0103 pentru capacitatea de distrugere a neutrofilelor, este concentrat\u0103 \u00een macrofage, este responsabil\u0103 de maturarea celulelor T (53) \u0219i promoveaz\u0103 fagocitoza \u0219i apoptoza neutrofilelor uzate. Prin urmare, nu este surprinz\u0103tor faptul c\u0103 infec\u021biile virale, \u00een func\u021bie de gravitatea lor, sunt asociate cu un metabolism crescut \u0219i cu ascorbat circulant redus.<\/div>\n<\/div>\n<div>\n<div dir=\"auto\">Vitamina C a \u00eembun\u0103t\u0103\u021bit supravie\u021buirea \u00een diferite modele murine de infec\u021bie letal\u0103. \u0218oarecii infecta\u021bi cu virusul encefalitei venezuelene \u0219i trata\u021bi cu vitamina C (50 mg \/ kg) prezint\u0103 jum\u0103tate din mortalitatea martorilor cu reduceri asociate ale titrurilor virale. \u0218oarecii incapabili s\u0103 sintetizeze vitamina C (nul L-Gulono-gamma-lacton oxidaz\u0103) au fost infecta\u021bi cu grip\u0103; \u0219oarecii care nu au primit vitamina C suplimentar\u0103 au prezentat scoruri mai mari de patologie pulmonar\u0103, \u00een ciuda niciunei diferen\u021be \u00een titrurile virale. La \u0219oarecii cu pneumonie indus\u0103 de virusul H1N1, vitamina C a redus mortalitatea \u00een func\u021bie de doz\u0103 (100% fa\u021b\u0103 de 80% fa\u021b\u0103 de 50% la 0; 125 \u0219i 250 mg \/ kg \/ zi) \u0219i a redus leziunile structurale capilare-alveolare. \u0218oarecii inocula\u021bi cu Rabie \u0219i trata\u021bi zilnic cu 100 mg \/ kg IMde vitamina C au prezentat aproape jum\u0103tate din mortalitatea martorilor.<\/div>\n<\/div>\n<div>\n<div dir=\"auto\">Singurul studiu uman cu privire la vitamina C a fost efectuat la solda\u021bii din URSS cu infec\u021bie viral\u0103 sever\u0103, indic\u00e2nd faptul c\u0103 suplimentarea cu vitamina C (300 mg \/ zi) i-a protejat de pneumonia asociat\u0103 gripei \u0219i a fost asociat\u0103 cu spitaliz\u0103ri mai scurte (58).<\/div>\n<div dir=\"auto\"><\/div>\n<\/div>\n<div>\n<div dir=\"auto\"><strong><br><\/strong><\/div>\n<div dir=\"auto\"><strong>Administrarea de vitamina C (iv 5 g \/ zi de dou\u0103 ori pe s\u0103pt\u0103m\u00e2n\u0103) la pacien\u021bii cu herpes zoster<\/strong> a prezentat o inciden\u021b\u0103 mai mic\u0103 a nevralgiei postherpetice (31,1% fa\u021b\u0103 de 57,1%), iar la sf\u00e2r\u0219itul studiului (s\u0103pt\u0103m\u00e2na 16) a existat un scor mai sc\u0103zut de durere \u00een tratament grup (0,64 +\/\u2212 0,9 vs. 1,98 +\/\u2212 0,7). Vitamina C administrat\u0103 la 1 g BID la 133 de pacien\u021bi, a redus riscul (SAU 0,25) de recuren\u021b\u0103 a cheratitei herpes simplex (HSK) , \u00een conformitate cu studiile anterioare care indic\u0103 disponibilitate redus\u0103 a ascorbatului \u00een ochi. Este de remarcat faptul c\u0103 un num\u0103r tot mai mare de rapoarte de cazuri de sindroame de detres\u0103 respiratorie acut\u0103 (ARDS) legate de virus indic\u0103 un tratament de succes cu doze mari de vitamina C intravenoase<\/div>\n<div dir=\"auto\"><br><\/div>\n<div dir=\"auto\"><span style=\"font-weight: bolder; color: rgb(122, 122, 122);\"><span style=\"font-weight: bolder;\">DAOfood\u00ae Plus<\/span><\/span><span style=\"color: rgb(122, 122, 122);\">&nbsp;este un produs nutraceutic cu utilizare medical\u0103 pentru gestionarea deficien\u021bei de DAO \u0219i a patologiilor sale asociate legate de intoleran<\/span><span style=\"color: rgb(122, 122, 122);\">\u021b<\/span><span style=\"color: rgb(122, 122, 122);\">a la histamin<\/span><span style=\"color: rgb(122, 122, 122);\">\u0103<\/span><span style=\"color: rgb(122, 122, 122);\">.<\/span><\/div>\n<div dir=\"auto\"><span style=\"color: rgb(122, 122, 122); font-size: 1rem;\">Fiecare comprimat con\u021bine pe lang<\/span><span style=\"color: rgb(122, 122, 122); font-size: 1rem;\">\u0103<\/span><span style=\"font-size: 1rem; color: rgb(122, 122, 122);\">&nbsp;enzima DAO, implicat<\/span><span style=\"color: rgb(122, 122, 122);\">\u0103<\/span><span style=\"font-size: 1rem; color: rgb(122, 122, 122);\">&nbsp;<\/span><span style=\"color: rgb(122, 122, 122);\">\u00ee<\/span><span style=\"font-size: 1rem; color: rgb(122, 122, 122);\">n degradarea histaminei excedentare din organism&nbsp;<\/span><span style=\"color: rgb(122, 122, 122);\">\u0219<\/span><span style=\"font-size: 1rem; color: rgb(122, 122, 122);\">i remisiunea simptomelor inflamatorii&nbsp;<\/span><span style=\"color: rgb(122, 122, 122);\">\u0219<\/span><span style=\"font-size: 1rem; color: rgb(122, 122, 122);\">i pseudoalergice, dou\u0103 ingrediente auxiliare \u2013 quercetin\u0103 (tableta galben\u0103) \u0219i vitamina C (tableta portocalie\/maronie). Ele nu numai c\u0103 cresc eficien\u021ba produsului, dar vitamina C este un puternic antioxidant, iar quercetina este un flavonoid cu multe avantaje pentru s\u0103n\u0103tate.<\/span><span style=\"font-size: 1rem; color: rgb(122, 122, 122);\">&nbsp;<\/span><\/div><div dir=\"auto\"><span style=\"color: rgb(122, 122, 122); font-size: 1rem;\">Capsula DAOfood\u00ae Plus este dezvoltat\u0103 folosind tehnologia inovatoare Eficaps\u00ae. Acestea sunt capsule gastrorezistente. Ele permit eliberarea ingredientelor la momentul optim, astfel \u00eenc\u00e2t produsul s\u0103 fie la fel de bioactiv \u0219i u\u0219or de digerat.<\/span><\/div>\n<div dir=\"auto\"><\/div>\n<div dir=\"auto\">Sursa:<\/div>\n<div dir=\"auto\">Colunga Biancatelli Ruben Manuel Luciano, Berrill Max, Catravas John D., Marik Paul E. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)<\/div>\n<div dir=\"auto\">Front. Immunol., 19 June 2020 | <a tabindex=\"0\" role=\"link\" href=\"https:\/\/doi.org\/10.3389\/fimmu.2020.01451?fbclid=IwAR2hOG7HxxqRpTDSaBbYzeCnbxYILFNM8fUyogJONS_F0VvV7TKrgji5DCQ\" target=\"_blank\" rel=\"nofollow noopener noreferrer\">https:\/\/doi.org\/10.3389\/<\/a>fimmu.2020.01451<span style=\"color: rgb(122, 122, 122); font-size: 1rem;\">\u00ee<\/span><\/div>\n<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Pare surprinz\u0103tor faptul c\u0103 laureatul premiului Nobel, Szent-Gyorgyi, a descoperit at\u00e2t acidul ascorbic (vitamina C), c\u00e2t \u0219i quercetina flavonoid\u0103 (la momentul respectiv etichetat\u0103 ca vitamina P). Acidul ascorbic este o vitamin\u0103 esen\u021bial\u0103 cu propriet\u0103\u021bi antivirale cunoscute , care este \u00een curs de investigare pentru efectele sale benefice \u00een timpul r\u0103spunsului la sepsis \u0219i la pacien\u021bii [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2789,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[191,128],"tags":[167,123,125,131,168,169,170],"_links":{"self":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/posts\/3389"}],"collection":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/comments?post=3389"}],"version-history":[{"count":0,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/posts\/3389\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/media\/2789"}],"wp:attachment":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/media?parent=3389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/categories?post=3389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/tags?post=3389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}