{"id":3381,"date":"2021-03-07T11:35:44","date_gmt":"2021-03-07T09:35:44","guid":{"rendered":"https:\/\/geneceutica.ro\/suplimentul-cu-diamine-oxidaza-dao-reduce-cefaleea-la-pacientii-cu-migrena-episodica-cu-deficit-de-dao\/"},"modified":"2023-03-22T15:23:01","modified_gmt":"2023-03-22T13:23:01","slug":"suplimentul-cu-diamine-oxidaza-dao-reduce-cefaleea-la-pacientii-cu-migrena-episodica-cu-deficit-de-dao","status":"publish","type":"post","link":"https:\/\/geneceutica.ro\/en\/suplimentul-cu-diamine-oxidaza-dao-reduce-cefaleea-la-pacientii-cu-migrena-episodica-cu-deficit-de-dao\/","title":{"rendered":"Suplimentul cu diamin-oxidaz\u0103 (DAO) reduce cefaleea la pacien\u021bii cu migren\u0103 episodic\u0103 cu deficit de DAO"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3381\" class=\"elementor elementor-3381 elementor-929\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8d90121 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8d90121\" data-element_type=\"section\" data-settings=\"{&quot;_ob_glider_is_slider&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25630a1\" data-id=\"25630a1\" data-element_type=\"column\" data-settings=\"{&quot;_ob_column_hoveranimator&quot;:&quot;no&quot;,&quot;_ob_column_has_pseudo&quot;:&quot;no&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2dab7a7a ob-harakiri-inherit ob-has-background-overlay elementor-widget elementor-widget-text-editor\" data-id=\"2dab7a7a\" data-element_type=\"widget\" data-settings=\"{&quot;_ob_use_harakiri&quot;:&quot;yes&quot;,&quot;_ob_harakiri_writing_mode&quot;:&quot;inherit&quot;,&quot;_ob_postman_use&quot;:&quot;no&quot;,&quot;_ob_widget_stalker_use&quot;:&quot;no&quot;,&quot;_ob_poopart_use&quot;:&quot;yes&quot;,&quot;_ob_shadough_use&quot;:&quot;no&quot;,&quot;_ob_allow_hoveranimator&quot;:&quot;no&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><strong>Intoleran\u021ba la histamin\u0103<\/strong> este o tulburare \u00een homeostazia histaminei datorat\u0103 unei degrad\u0103ri intestinale reduse a acestei amine, cauzat\u0103 \u00een principal de o deficien\u021b\u0103 a enzimei diamin oxidaz\u0103 (DAO). Printre simptomele legate de histamin\u0103, cefaleea este una dintre cele mai \u00eenregistrate. Strategiile clinice actuale pentru tratamentul simptomatologiei legate de aceast\u0103 tulburare se bazeaz\u0103 pe excluderea alimentelor cu histamin\u0103 sau alte amine bioactive \u0219i \/ sau suplimentarea DAO exogen\u0103. Scopul acestui studiu efectuat de cercet\u0103torii spanioli a fost de a evalua eficacitatea unui supliment alimentar const\u00e2nd din enzima DAO ca tratament preventiv al migrenei la pacien\u021bii cu deficit de DAO printr-un studiu randomizat dublu-orb.<\/p><p>100 de pacien\u021bi cu migren\u0103 episodic\u0103 confirmat\u0103 \u00een conformitate cu criteriile actuale ale Societ\u0103\u021bii Interna\u021bionale a Cefaleei (IHS) \u0219i cu deficit de DAO (niveluri sub 80 HDU \/ ml) au fost randomiza\u021bi \u00een dou\u0103 grupuri. Un grup a primit supliment de enzime DAO, iar cel\u0103lalt a primit placebo timp de o lun\u0103. Rezultatele clinice evaluate au fost durata \u0219i num\u0103rul de atacuri, percep\u021bia intensit\u0103\u021bii durerii \u0219i efectele adverse \u00een timpul tratamentului. A fost \u00eenregistrat\u0103 \u0219i utilizarea triptanilor.<\/p><p>S-a constatat o mare variabilitate \u00een durata atacurilor de migren\u0103 raportate de grupurile placebo \u0219i DAO. O reducere semnificativ\u0103 (p = 0,0217) a orelor de durere a fost realizat\u0103 la pacien\u021bii trata\u021bi cu supliment DAO, cu durate medii de 6,14 (\u00b1 3,06) \u0219i 4,76 (\u00b1 2,68) ore \u00eenainte \u0219i respectiv dup\u0103 tratament. O reducere mai mic\u0103 f\u0103r\u0103 semnifica\u021bie statistic\u0103 a fost, de asemenea, observat\u0103 pentru acest rezultat \u00een grupul placebo, de la 7,53 (\u00b1 4,24) la 6,68 (\u00b1 4,42) ore. Doar \u00een grupul DAO, s-a observat o sc\u0103dere a procentului de pacien\u021bi care au luat triptani. Num\u0103rul de atacuri \u0219i scorurile intensit\u0103\u021bii durerii au ar\u0103tat o reducere similar\u0103 \u00een ambele grupuri. Nu s-au \u00eenregistrat efecte adverse la pacien\u021bii trata\u021bi cu enzim\u0103 DAO.<\/p><p>Concluzii: Pacien\u021bii migreno\u0219i suplimenta\u021bi cu enzim\u0103 DAO timp de o lun\u0103 au redus semnificativ durata atacurilor de migren\u0103 cu 1,4 ore. Nu s-a g\u0103sit nicio reducere semnificativ\u0103 statistic \u00een grupul placebo \u00eenainte \u0219i dup\u0103 tratament. Reducerea orelor de durere observate \u00een grupul placebo (0,9 ore) ar putea explica lipsa diferen\u021belor semnificative \u00eentre ambele grupuri de studiu. O lun\u0103 de suplimentare DAO a demonstrat o tendin\u021b\u0103 pozitiv\u0103 \u00een \u00eembun\u0103t\u0103\u021birea migrenei, dar sunt necesare mai multe studii cu o perioad\u0103 mai lung\u0103 de tratament pentru a evalua mai bine eficacitatea supliment\u0103rii DAO.<\/p><p>Reference:<\/p><p><span style=\"color: #212121; font-family: BlinkMacSystemFont, -apple-system, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Fira Sans', 'Droid Sans', 'Helvetica Neue', sans-serif; font-size: 1rem;\">Izquierdo-Casas J, Comas-Bast\u00e9 O, Latorre-Moratalla ML, Lorente-Gasc\u00f3n M, Duelo A, Soler-Singla L, Vidal-Carou MC. Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial. Clin Nutr. 2019 Feb;38(1):152-158. doi: 10.1016\/j.clnu.2018.01.013. Epub 2018 Feb 15. PMID: 29475774. Abstract.<\/span><\/p><p>#suplimentareaDAO #Diamin_oxidaz\u0103 #Histamina #Intoleran\u021b\u0103 la histamin\u0103 #Migren\u0103.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Intoleran\u021ba la histamin\u0103 este o tulburare \u00een homeostazia histaminei datorat\u0103 unei degrad\u0103ri intestinale reduse a acestei amine, cauzat\u0103 \u00een principal de o deficien\u021b\u0103 a enzimei diamin oxidaz\u0103 (DAO). Printre simptomele legate de histamin\u0103, cefaleea este una dintre cele mai \u00eenregistrate. Strategiile clinice actuale pentru tratamentul simptomatologiei legate de aceast\u0103 tulburare se bazeaz\u0103 pe excluderea alimentelor [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2793,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[191,128],"tags":[],"_links":{"self":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/posts\/3381"}],"collection":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/comments?post=3381"}],"version-history":[{"count":0,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/posts\/3381\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/media\/2793"}],"wp:attachment":[{"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/media?parent=3381"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/categories?post=3381"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/geneceutica.ro\/en\/wp-json\/wp\/v2\/tags?post=3381"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}